Michal Novak Selected Research

tau Proteins (tau Protein)

1/2020	Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies.
1/2020	Environmental Enrichment Rescues Functional Deficit and Alters Neuroinflammation in a Transgenic Model of Tauopathy.
10/2018	FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease.
8/2018	Dendritic Cells as an Alternate Approach for Treatment of Neurodegenerative Disorders.
1/2018	Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead.
1/2018	Stress-Induced Alterations of Immune Profile in Animals Suffering by Tau Protein-Driven Neurodegeneration.
1/2018	Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation.
2/2017	Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial.
1/2017	Changes of Cerebrospinal Fluid Peptides due to Tauopathy.
1/2017	The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.

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Michal Novak Research Topics

Disease

37	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 01/2003
31	Tauopathies 01/2020 - 08/2006
9	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2004
6	Neuroinflammatory Diseases 01/2020 - 10/2010
3	Cognitive Dysfunction 10/2018 - 08/2006
2	Inflammation (Inflammations) 01/2020 - 04/2009
2	Disease Progression 01/2020 - 08/2018
2	Sarcoma (Soft Tissue Sarcoma) 12/2016 - 03/2016
2	Amyloid Plaque 03/2016 - 09/2009
2	Parkinson Disease (Parkinson's Disease) 01/2013 - 10/2006
2	Frontotemporal Dementia (Semantic Dementia) 07/2009 - 08/2004
1	COVID-19 02/2022
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2020
1	Chronic Traumatic Encephalopathy 01/2020
1	Atrophy 10/2018
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 03/2016
1	Proteostasis Deficiencies 10/2015
1	Neuroblastoma 01/2011
1	Pathologic Processes 12/2008
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/2006
1	Paratuberculosis (Johne's Disease) 01/2006
1	Neoplasms (Cancer) 05/2005
1	Hypoxia (Hypoxemia) 05/2005

Drug/Important Bio-Agent (IBA)

38	tau Proteins (tau Protein)IBA 01/2020 - 01/2003
10	Proteins (Proteins, Gene)FDA Link 01/2017 - 06/2004
6	Intrinsically Disordered ProteinsIBA 01/2017 - 12/2006
5	Pharmaceutical PreparationsIBA 07/2012 - 08/2006
4	AntibodiesIBA 02/2022 - 09/2009
4	Monoclonal AntibodiesIBA 01/2014 - 01/2003
3	VaccinesIBA 08/2018 - 01/2014
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 09/2009
3	Inosine Diphosphate (IDP)IBA 10/2012 - 12/2006
3	Protein Isoforms (Isoforms)IBA 07/2009 - 10/2006
3	EpitopesIBA 12/2006 - 01/2003
2	AADvac1IBA 10/2018 - 02/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 01/2016
2	Interleukin-10 (Interleukin 10)IBA 01/2018 - 01/2016
2	Amyloid (Amyloid Fibrils)IBA 01/2018 - 03/2016
2	Peptides (Polypeptides)IBA 01/2017 - 07/2010
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2017 - 10/2006
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2016 - 02/2014
2	SolutionsIBA 10/2012 - 12/2006
1	Immunoglobulin G (IgG)IBA 10/2018
1	Amyloid beta-PeptidesIBA 08/2018
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2018
1	Sulfhydryl Compounds (Thiols)IBA 01/2017
1	DNA-Binding Proteins (DNA Binding Protein)IBA 03/2016
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016
1	Phenylalanine (L-Phenylalanine)FDA Link 01/2016
1	KynurenineIBA 01/2016
1	Tyrosine (L-Tyrosine)FDA Link 01/2016
1	Tryptophan (L-Tryptophan)FDA Link 01/2016
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2015
1	UbiquitinIBA 10/2015
1	HomocysteineIBA 07/2015
1	HSP27 Heat-Shock ProteinsIBA 07/2015
1	Histamine (Histamine Dihydrochloride)FDA Link 02/2014
1	Epinephrine (Adrenaline)FDA LinkGeneric 02/2014
1	Dopamine (Intropin)FDA LinkGeneric 02/2014
1	Serotonin (5 Hydroxytryptamine)IBA 02/2014
1	3,4-Dihydroxyphenylacetic AcidIBA 02/2014
1	Neurotransmitter Agents (Neurotransmitter)IBA 02/2014
1	Aminobutyrates (Aminobutyric Acid)IBA 02/2014
1	Glutamic Acid (Glutamate)FDA Link 02/2014
1	AcidsIBA 02/2014
1	gamma-Aminobutyric Acid (GABA)IBA 02/2014
1	Congo RedIBA 07/2012
1	thioflavin TIBA 07/2012
1	Doxycycline (Periostat)FDA LinkGeneric 01/2011
1	Caspase 3 (Caspase-3)IBA 01/2011
1	Amyloidogenic ProteinsIBA 09/2009
1	ProteomeIBA 03/2009
1	Free RadicalsIBA 01/2009
1	ImmunosorbentsIBA 12/2006
1	EnzymesIBA 12/2006
1	alpha-SynucleinIBA 10/2006
1	Prion ProteinsIBA 10/2006
1	Molecular Probes (Molecular Probe)IBA 10/2006
1	DNA (Deoxyribonucleic Acid)IBA 01/2006
1	Messenger RNA (mRNA)IBA 05/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2005
1	Indicators and Reagents (Reagents)IBA 05/2005
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 05/2005
1	Protein Kinases (Protein Kinase)IBA 08/2004

Therapy/Procedure

6	Immunotherapy 01/2020 - 09/2009
5	Therapeutics 02/2022 - 01/2009
2	Immunomodulation 01/2012 - 10/2010
1	Lasers (Laser) 01/2017
1	Cell- and Tissue-Based Therapy (Cell Therapy) 01/2013